COLD-fX is a patented highly purified natural product obtained from roots of North American ginseng. It is comprised of poly-furanosyl-pyranosyl-saccharides. Through CVT’s proprietary, patented ChemBioPrint process, COLD-fX undergoes vigorous testing to ensure that every batch has the same chemical identity and biological activity. Each capsule contains 200 mg of dried extract, CVT-E002, which has been shown in laboratory and clinical studies to stimulate our immune system and has demonstrated efficacy and safety in the prevention and treatment of cold and flu infections. The patent for CVT-E002 covers its unique chemical composition, manufacturing method, and indications for therapeutic use.
 

CVT's patented, precise ChemBioPrint Technology isolates and standardizes complex molecules obtained from natural sources. Due to the ChemBioPrint extraction process the result allows only the safe and active ingredients to be utilized. The ChemBioPrint process ensures that each capsule consistently contains the same amount of active ingredient. In addition, each batch is tested for biological effectiveness. The quality assurance of this precise manufacturing leads to measurable chemical and biological consistency from batch to batch.

Most ginseng products on the market are Asian ginseng (Panax ginseng sp.). COLD-fX is a highly purified extract derived from North American ginseng (Panax quinquefolius sp.) which has a very different chemical and biological profile than Asian ginseng. Because COLD-fX is comprised of specific active viral-targeted, immune-enhancing molecules, oligo- and poly- saccharides, it doesn’t exhibit the other effects typically associated with ginseng products such as enhanced vitality, mental alertness and mood improvements. Although COLD-fX is a natural extract of North American ginseng, its highly purified and precise chemical composition makes comparison with "ginseng" in general, inappropriate. Comparing COLD-fX with raw ginseng roots is like comparing acetylsalicylic acid (the active ingredient in Aspirin) with willow tree bark (acetylsalicylic acid was originally isolated from willow tree bark).
 

Oligosaccharides and polysaccharides are types of complex carbohydrates. They are very large molecules composed of different combinations of monosaccharide units (sugars). They are not simply the equivalent of consuming other complex carbohydrates such as starch, or simple sugars. This is because the complex shape and arrangement of the poly- and oligo- saccharides means the molecules are able to specifically induce unique biochemical effects which enhance the immune system. CVT-E002, the active ingredient in COLD-fX®, is comprised specifically of poly-furanosyl-pyranosyl-saccharides.
 

A number of studies, including both experimental and clinical, have shown that COLD-fX stimulates the immune system. These effects were found on both the innate and the acquired immune system and both cell-mediated and humoral (antibody)- mediated immunity have been shown to be enhanced.

There are numerous pharmaceutical options for the relief of cold and flu-like symptoms, such as antihistamines, NSAIDs, decongestants, and cough suppressants. However, because these only address the symptoms, the underlying viral infection goes un-treated and may even be prolonged.

To date, 7 well-controlled clinical trials involving a diverse population of up to 685 subjects, have been carried out on COLD-fX. In all these trials, COLD-fX has been found to be highly effective in the prevention as well as treatment of cold and flu infections. It was also found to be safe and well-tolerated for prolonged use.
 

COLD-fX is manufactured in Canada by CV Technologies. CV Technologies is an Alberta based company since 1992.

COLD-fX can be used both for the prevention as well as treatment of cold and flu infections.
 

No studies have yet been done to assess the efficacy or safety of COLD-fX use in a pediatric population. We are hoping to have these types of clinical studies performed with COLD-fX in the near future.
 

COLD-fX can be taken preventatively on a long-term basis at two capsules per day. An acute dosing regimen of COLD-fX may also be followed. COLD-fX is most noticeably effective if taken at the first onset of symptoms, although it may also be used if taken at a later stage of infection.
 

No adverse effects of COLD-fX® are observed in laboratory studies when given at 500 times higher than the recommended dose at one time and 25 times higher than the recommended dose for 30 days. In clinical studies and for usage in the general population, adverse effects have also not been associated with the recommended acute dosing regimen and the preventative chronic dosing regimen. Although there are no known interactions with drugs, herbs, or disease conditions, individuals with a serious autoimmune disorder or other serious medical conditions should consult a physician before taking COLD-fX®. As COLD-fX® is a derivative of North American ginseng, those with known allergies or sensitivities to ginseng should avoid consumption of COLD-fX®.
 

Laboratory studies have indicated that COLD-fX does not overstimulate the immune system, but rather induces more moderate changes in the immune system which reflect healthy levels of immune system components such as cytokines and natural killer (NK) cells. Clinical studies have also demonstrated that COLD-fX consumption is not associated with overstimulation of the immune system.
 

There are no known interactions of COLD-fX with other medications. Laboratory studies have demonstrated no effect of COLD-fX on the major drug-metabolizing enzymes of the liver. Additionally, the active ingredients of COLD-fX, oligo- and poly- saccharides, are very large molecules. This means they are unlikely to enter the bloodstream and instead exert immune-stimulating effects in the gastrointestinal tract, although this remains to be confirmed in scientific studies. Thus, COLD-fX is thought to exhibit a low likelihood of interaction with other drugs. However, since specific clinical trials have not yet been conducted to investigate this interaction potential, it is advised that individuals taking other medications consult a health-care practitioner before using COLD-fX.
 

COLD-fX has been demonstrated safe and effective in healthy individuals. Clinical trials have not been conducted specifically in populations with autoimmune diseases. Individuals with arthritis were permitted to participate in our FDA-regulated trials in seniors and the frequency of adverse events was not different in the COLD-fX versus the placebo (control) group. For other more serious autoimmune conditions such as lupus and multiple sclerosis, we recommend consulting a physician before taking COLD-fX. Our laboratory studies suggest that COLD-fX is unlikely to interact with other medications, including drugs used to treat autoimmune conditions, but to be safe, please speak to a health care provider if you are taking these medications before consuming COLD-fX.
 

COLD-fX has been demonstrated safe and effective in healthy individuals. Clinical trials have not been conducted specifically in diabetic populations. Individuals with diabetes were permitted to participate in our FDA-regulated trials in seniors; blood glucose was not affected by COLD-fX intake and the frequency of adverse events was not different in the COLD-fX versus the placebo (control) group. However, to ensure that COLD-fX is safe to consume in your specific situation, we recommend consulting a physician and monitoring of general health and glucose levels when taking COLD-fX. Our laboratory studies suggest that COLD-fX is unlikely to interact with other medications, including antidiabetic drugs, but to be safe, please speak to a health care provider if you are taking these medications before consuming COLD-fX.
 

COLD-fX has been demonstrated safe and effective in healthy individuals. Clinical trials have not been conducted specifically in populations with high blood pressure. Individuals with high blood pressure were permitted to participate in our FDA-regulated trials in seniors; although blood pressure was not specifically assessed, there were no adverse events related to blood pressure regulation associated with COLD-fX intake. However, to ensure that COLD-fX is safe to consume in your specific situation, we recommend consulting a physician and monitoring of general health and blood pressure when taking COLD-fX. Our laboratory studies suggest that COLD-fX is unlikely to interact with other medications, including antihypertensive drugs, but to be safe, please speak to a health care provider if you are taking these medications before consuming COLD-fX.
 

High doses of some forms of ginseng which are high in ginsenosides have been shown to affect the metabolism and effect of blood thinners such as coumadin (warfarin). Although COLD-fX is composed of molecules (oligosaccharides and polysaccharides) which are not thought to cause drug interactions, and laboratory and clinical studies have indicated that the likelihood of a drug interaction with COLD-fX is greatly reduced, to be safe, individuals taking coumadin are advised to avoid consumption of COLD-fX.
 

Since no studies have yet been carried out on use of COLD-fX during pregnancy or nursing, it is recommended that you consult a physician before consuming COLD-fX.